Urethane therapy in leukemia.
نویسندگان
چکیده
T HE purpose of this paper is to report the results of urethane therapy of the leukemias, based on a study of 2.4 patients. In April, 1946, Haddow and Sexton’ described the influence of various carbamic esters on experimental rat cancers. Ethyl carbamate (urethane) yielded the best results. It alone produced inhibition of tumor growth and fibrous replacement of the cancerous rat tissue. For this reason, and since urethane is relatively nontoxic for humans and is easily obtainable, the experiments were transferred to human subjects with carcinoma of the breast and other malignancies. The results were generally disappointing. It was, however, noted that a few of these patients developed leukopenia while taking urethane. This observation motivated, in 1943, the first clinical trial of the effects of urethane in leukemia and allied disorders. In May, 1946, Paterson, Haddow, Thomas, and Watkinson2 reported the results of urethane treatment of p. leukemic patients. The drug was administered orally in an average dose of 3 tO 4 grams daily. The drug proved “effective” in approximately one-third of the patients, producing in this “favorable group” reduction in size of enlarged spleens and of lymph nodes and causing reversion of the blood picture to more normal values. These workers found the urethane effect to be approximately equal in value to that of standard deep x-ray therapy in a control series of similar cases. Of their 32. urethane-treated patients, 19 had myelogenous .leukemia; and 8 of these were benefited. Clinical and hematologic remissions were maintained for periods of 2. tO 6 months. Of 13 patients with lymphatic leukemia, 2.
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عنوان ژورنال:
- The Review of gastroenterology
دوره 16 3 شماره
صفحات -
تاریخ انتشار 1948